Antiviral Medications in Eye Care

Pharmaceutical Management with Ophthalmic Antivirals

Antiviral medications play a critical role in the management of viral eye infections, such as herpes simplex keratitis and herpes zoster, which can pose significant threats to ocular health if left untreated. These medications are designed to target and inhibit the replication of viruses, thereby reducing the severity of symptoms and preventing the progression of the infection. For eye care professionals, understanding the mechanism of action, proper dosing, and potential side effects of antiviral agents is essential for effective treatment.

Topical antivirals, such as ganciclovir gel, and systemic antivirals, like acyclovir and valacyclovir, are commonly used to manage these infections. Topical treatments are often preferred for their direct action on the affected ocular tissues, while systemic medications may be necessary for more severe or widespread infections. These drugs work by interfering with viral DNA synthesis, thereby halting the replication process and allowing the immune system to control the infection more effectively.

Early diagnosis and prompt initiation of antiviral therapy are key to preserving vision and preventing complications associated with viral ocular diseases. Timely and appropriate use of these medications can significantly reduce the risk of long-term damage to ocular structures and help maintain optimal visual health. Optometrists must stay informed about the latest antiviral treatments and their application to ensure they can provide the best possible care for patients with viral eye infections.

BrandGenericDosingAmountAgesPregnancyMechanism
Famvir
GenericPO
famciclovir250mg po tid x7d (simplex)
500mg po tid x7d (zoster)
125/250/500mgNABguanine analogue
Valtrex
GenericPO
valcyclovir500mg po tid (simplex)
1g po tid x7d (zoster)
500mg/1g>12 yearsBguanine analogue
Viroptic
Generic
trifluridine 1%q2h 24-48h, then qid7.5mL>6 yearsCDNA synthesis interference
Zirgan
Generic
ganciclovir 0.15%5x/d, then tid x7d5g (gel)>2 yearsCDNA synthesis interference
Zovirax
GenericPO
acyclovir400mg po 5x/d x7d (simplex)
800mg po 5x/d x7d (zoster)
200/400/800mg>2 yearsBinhibits DNA polymerase