Glaucoma Medications in Eye Care

Glaucoma Medication Management

Glaucoma medications play a critical role in the management of intraocular pressure (IOP), which is a crucial factor in preventing optic nerve damage and preserving vision in conditions such as open-angle glaucoma and angle-closure glaucoma. These medications work through various mechanisms to lower IOP, either by reducing the production of aqueous humor or by increasing its outflow from the eye. The primary classes of glaucoma treatments include beta-blockers, prostaglandin analogs, alpha agonists, carbonic anhydrase inhibitors, and cholinergic agents, each with its own unique mode of action and potential side effects. Additionally, combination medications that contain two different classes of drugs are available to enhance treatment efficacy and improve patient compliance.

Glaucoma Medications

BrandGenericDosingAmountAgesPregnancyMechanism
Alphagan P
Generic
brimonidine 0.1/0.15/0.2*%tid5/10/15mL>2 yearsBα-2 agonist
↓ aqueous production
↑ outflow
Azopt
Generic
brinzolamide 1%tid5/10/15mLNACcarbonic anhydrase inhibitor
↓ aqueous production
Combigan
Generic
brimonidine 0.2%
timolol 0.5%
bid5/10/15mL>2 yearsCα-2 agonist
β blocker
↓ aqueous production, ↑ outflow
Cosopt
Generic
dorzolamide 2%
timolol 0.5%
bid5/10mL>2 yearsCcarbonic anhydrase inhibitor
β blocker
↓ aqueous production
Diamox
GenericPO
acetazolamide500mg po bid125/250mg
500mg 'Sequels'
>12 yearsCcarbonic anhydrase inhibitor
↓ aqueous production
Isopto Carpine
Generic
pilocarpine 1/2/4%qd-qid15mL>2 yearsCcholinergic agonist
↑ outflow
Lumigan
Generic
bimatoprost 0.01/0.03*%qhs2.5/5/7.5mL>16 yearsCprostaglandin analogue
↑ outflow
Rhopressa
netarsudil 0.02%qhs2.5mLNANARho kinase inhibitor
↑ outflow
Rocklatan
netarsudil 0.02%
latanoprost 0.005%
qhs2.5mLNANARho kinase inhibitor
prostaglandin analogue
↑ outflow
Simbrinza
brimonidine 0.2%
brinzolamide 1%
tid8mL>2 yearsCα-2 agonist
carbonic anhydrase inhibitor
↓ aqueous production
↑ outflow
Timoptic
Generic
timolol maleate 0.25/0.5%bid5/10/15mL>2 yearsCβ blocker
↓ aqueous production
Travatan Z
Generic
travoprost 0.004%qhs2.5/5mL>16 yearsCprostaglandin analogue
↑ outflow
Trusopt
Generic
dorzolamide 2%bid-tid5/10mL>2 yearsCcarbonic anhydrase inhibitor
↓ aqueous production
Vyzulta
latanoprostene bunod 0.024%qhs5mL>16 yearsNAprostaglandin analogue
↑ outflow
Xalatan
Generic
latanoprost 0.005%qhs2.5mLNACprostaglandin analogue
↑ outflow
Xelpros
latanoprost 0.005%
(BAK free)
qhs2.5mLNACprostaglandin analogue
↑ outflow
Zioptan
tafluprost 0.0015%qhs30/90 packNot RecommendedCprostaglandin analogue
↑ outflow