Does the two-week replacement period start at opening or only on wear days?

Biweekly lenses follow a 14-day calendar schedule from opening/first wear, not a count of wear days; they should be discarded at the end of the two-week interval.

Are hydrogen peroxide systems appropriate for biweekly lenses?

Hydrogen peroxide systems are often a good choice for biweekly lenses if patients use the correct case, allow full neutralization, and follow manufacturer instructions carefully.

How do biweekly lenses compare to daily disposables on cost?

For adherent full-time wearers, biweekly lenses are usually less expensive per year than premium daily disposables; for part-time wear, daily lenses can be more economical overall.

Biweekly (2-Week) Replacement Contact Lens Guide

Fourteen-day replacement schedule for reusable soft lenses

Biweekly Replacement Contact Lenses

Where a 2-week schedule fits clinically

Biweekly lenses (14-day replacement) occupy a middle ground between monthly and daily modalities. They can be useful for full-time wearers who experience end-of-cycle discomfort, drying, or deposit-related symptoms in monthly lenses but who are not ready to move to full-time daily disposables. Replacing the lens every two weeks provides a fresher surface than monthly wear while typically remaining more cost-efficient than premium daily lenses for patients who are adherent to care instructions.

Replacement tracking and adherence challenges

The main practical limitation of biweekly lenses is calendar tracking. Unlike an easy "first of the month" cue with monthly lenses, a 14-day cycle requires more deliberate reminders. Patients may unintentionally extend wear to three or four weeks, which erodes the hygiene advantage and can increase the risk of deposit-related complications, including papillary responses and infiltrative events. Providing clear written instructions, simple reminder strategies (such as marking replacement dates or using app-based alerts), and reinforcing the true 2-week interval are important parts of successful biweekly prescribing.

Linking biweekly lenses with appropriate care systems

As with other reusable modalities, biweekly lenses depend on effective cleaning and disinfection between wears. Patients should be instructed to rub and rinse lenses after removal and to store them in fresh solution in a clean case. Hydrogen peroxide systems can be particularly helpful for managing lipid and protein deposits, provided that neutralization is completed and manufacturer instructions are followed. When biweekly wearers continue to struggle with deposits or adherence despite optimized care systems, moving to daily disposables or, in some cases, to monthly lenses with a different material and care strategy may be more effective.

Biweekly Replacement Sphere Contact Lenses

Brand	Material	Dk	BC	Dia	Sph / Steps
Acuvue 2 Biweekly6	etafilcon A	25.5	8.3/8.7	14	+8.00 to -12.000.25, 0.50 over ± 6.00
Acuvue Oasys SiHyBiweekly12/24	senofilcon A	147	8.4/8.8	14	+8.00 to -12.000.25, 0.50 over ± 6.00
Acuvue Oasys with Transitions SiHyBiweekly6	senofilcon A	121	8.4/8.8	14	+8.00 to -12.000.25, 0.50 over ± 6.00
Avaira Vitality SiHyBiweekly6	fanfilcon A	110	8.4	14.2	+8.00 to -12.000.25, 0.50 over ±6.00
Biomedics 55 Premier Biweekly6	ocufilcon D	28	8.6/8.8/8.9	14.2	8.6/8.9: -0.25 to -10.008.8: +0.25 to +6.000.25, 0.50 over +5.00
Extreme H20 59 Biweekly6	hioxifilcon A	28	8.3 (Xtra)8.6 (Thin & Xtra)	14.2	8.3: -1.00 to -8.008.6: +1.00 to +6.00, -0.50 to -8.000.25, 0.50 over +4.00/-6.00
Freshlook Colors/Colorblends/Dimensions Biweekly6	phemfilcon A	16	8.6	14.5	+6.00 to -8.000.25, 0.50 over +2.00/-6.00
SofLens 38 Biweekly6	polymacon	24	8.4/8.7/9.0	14	+4.00 to -9.000.25

Biweekly Replacement Toric Contact Lenses

Brand	Material	Dk	BC	Dia	Sph / Steps	Cyl / Axis
Acuvue Oasys for Astigmatism SiHyBiweekly6	senofilcon A	129	8.6	14.5	+6.00 to -9.000.25, 0.50 over -6.00	-0.75 to -2.75(10° full)
Avaira Vitality Toric SiHyBiweekly6	fanfilcon A	90	8.5	14.5	+8.00 to -10.000.25, 0.50 over ±6.00	-0.75 to -2.25(10° full)
Biomedics Toric Biweekly6	ocufilcon D	17.8	8.7	14.5	+6.00 to -9.000.25, 0.50 over -6.00	-0.75 to -2.2510° full
SofLens Toric Biweekly6	alphafilcon A	16	8.5	14.5	+6.00 to -9.000.25, 0.50 over -6.00, -2.75cyl: (pl to -9.00 only)	-0.75 to -2.75(10° full)

Biweekly Replacement Multifocal Contact Lenses

Brand	Material	Dk	BC	Dia	Sph / Steps	Add
Acuvue Oasys Multifocal SiHyBiweekly6	senofilcon A	147	8.4	14.3	+6.00 to -9.000.25	Low (+0.75 to +1.25)Mid (+1.50 to +1.75)High (+2.00 to +2.50)

Biweekly Contact Lens FAQs

Does the two-week replacement period start at opening or only on wear days?: For most biweekly lenses, the replacement interval is based on calendar days from the time the blister pack is opened or the lens is first worn, not on the number of days it is actually on the eye. Once a lens is in use, it should be discarded at the end of the labeled two-week period according to the manufacturer's instructions, even if it was not worn every single day. Counseling patients to treat biweekly lenses as a 14-day device rather than a "14 wear" device helps prevent unintentional stretching of the schedule.
Are hydrogen peroxide systems appropriate for biweekly lenses?: Yes. Many biweekly wearers do well with hydrogen peroxide care systems, which provide thorough disinfection and can help manage lipid and protein deposits when used correctly. Patients must use the dedicated peroxide case, allow full neutralization before lens insertion, and follow both the solution and lens manufacturer recommendations closely. For patients who are unlikely to follow peroxide instructions reliably, a high-quality multipurpose solution may be safer.
How do biweekly lenses compare to daily disposables on cost?: For full-time wearers who adhere to replacement and care instructions, biweekly lenses are generally less expensive per year than premium daily disposables. For part-time or occasional wear, daily disposables can be more economical because lenses are only used on days they are worn and do not require ongoing solution and case replacement. Cost discussions should consider both wear pattern and care system, not just the price per box.